P118
法洛芬
solid
别名:
3-氨基-2-（4-氯苯基）丙烷膦酸
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关于此项目
经验公式（希尔记法）:
C9H13ClNO3P
化学文摘社编号:
分子量:
249.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
form
solid
Quality Level
impurities
≥97% (NMR)
color
white
solubility
0.1 M HCl: 13.3 mg/mL, methanol: 19.3 mg/mL, DMSO: insoluble
SMILES string
NCC(CP(O)(O)=O)c1ccc(Cl)cc1
InChI
1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChI key
VSGNGLJPOGUDON-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
General description
法克罗芬是巴氯芬的膦酸衍生物。
Application
法克罗芬已用于阻断 GABAB 受体。
Biochem/physiol Actions
法克罗芬在鉴定与 GABA 和（−）巴氯芬相互作用的中枢和外周荷包牡丹碱不敏感受体的生理重要性的研究中起着重要作用。法克罗芬可作为 GABAB 受体拮抗剂。法克罗芬具有可逆性阻断已记录在猫和大鼠背外侧膝状核的投射细胞中和大鼠海马 CA1 锥体神经元中的晚的、荷包牡丹碱耐药性、K+ 依赖性抑制性突触后电位（IPSP）的能力。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones
Soltesz I, et al.
Brain Research, 448(2), 351-354 (1988)
Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes.
Wang B, et al.
Faseb Journal, 24(10), 4078-4088 (2010)
H Hasuo et al.
Neuroscience letters, 86(1), 77-81 (1988-03-21)
Phaclofen has recently been described as an antagonist to baclofen at both peripheral and central receptors. We have applied phaclofen in known concentrations to an isolated rat brain slice preparation containing the septal nuclei. Our data demonstrate that phaclofen antagonizes
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P118-5MG | 04061834354208 |
| P118-100MG | 04061833007938 |
| P118-25MG | 04061833007945 |