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P1269

佛波醇 12,13-二丁酸酯

≥98% (TLC), powder, PKC activator

别名:

二丁酸佛波醇酯

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关于此项目

经验公式（希尔记法）:
C28H40O8
化学文摘社编号:
37558-16-0
分子量:
504.61
NACRES:
NA.77
PubChem Substance ID:
24898178
UNSPSC Code:
12352211
MDL number:
MFCD00036783
Beilstein/REAXYS Number:
6551234
Assay:
≥98% (TLC)
Form:
powder
Quality level:
100
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产品名称

佛波醇 12,13-二丁酸酯, ≥98% (TLC), powder

Quality Level

100

assay

≥98% (TLC)

form

powder

color

clear light yellow

solubility

H2O: 30 μM, DMSO: soluble, acetone: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC

InChI

1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

InChI key

BQJRUJTZSGYBEZ-YVQNUNKESA-N

Gene Information

mouse ... Prkcd(18753)

Application

佛波醇12,13-二丁酸酯（二丁酸佛波醇酯）已用作蛋白激酶C(PKC)激活剂，用于研究其对人有机阴离子转运蛋白4(hOAT4)活性的影响。作为PKC激活剂，它也已用于分析其对HL-1细胞中半乳凝素-3表达和基质产生的影响。

Biochem/physiol Actions

佛波醇12,13-二丁酸酯(PDBu)是蛋白激酶C(PKC)的强效激活剂。它的亲水性高于佛波醇12-肉豆蔻酸酯13-乙酸酯(PMA)，方便在组织培养中将PDBu洗出细胞。PDBu可激活原代人脐静脉内皮细胞的内皮型一氧化氮合酶表达，进而影响PKCα和ε表达。

Features and Benefits

疏水性低于 PMA，更容易在组织培养中洗掉细胞。

Preparation Note

贮备液不能在水性介质中制备；在水介质中稀释至工作浓度前，溶于可溶于水的有机溶剂中。

Disclaimer

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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCR0830
MKCQ1639
MKCP8104
MKCN8977
MKCN6824

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Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension
Kazuhiro Irie et al.
Pharmacology & therapeutics, 93(2-3), 271-281 (2002-08-23)
Conventional and novel protein kinase C (PKC) isozymes contain two cysteine-rich C1 domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu)-binding sites. We synthesized C1 peptides of 50-70 residues corresponding to all PKC isozyme C1 domains using
Mayumi Shindo et al.
The Journal of biological chemistry, 278(20), 18448-18454 (2003-03-07)
Diacylglycerol kinase (DGK) and protein kinase C (PKC) are two distinct enzyme families associated with diacylglycerol. Both enzymes have cysteine-rich C1 domains (C1A, C1B, and C1C) in the regulatory region. Although most PKC C1 domains strongly bind phorbol esters, there
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