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P148

4α-佛波醇12-十四酸酯13-乙酸酯

Name: 4α-佛波醇12-十四酸酯13-乙酸酯
Brand: SIGMA

solid, ≥95% (TLC)

别名:

4α-PMA

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关于此项目

经验公式（希尔记法）:

C₃₆H₅₆O₈

化学文摘社编号:

63597-44-4

分子量:

616.83

NACRES:

NA.77

PubChem Substance ID:

24898203

UNSPSC Code:

12352211

MDL number:

MFCD00153860

Assay:

≥95% (TLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥95% (TLC)

form

solid

color

white

solubility

H₂O: ~2 μM, DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-LQLWEASQSA-N

说明

General description

本品虽然具有水溶性，但建议先将其溶解于与水混溶的有机溶剂中，然后在水性介质中稀释至工作浓度。

Biochem/physiol Actions

蛋白质激酶C佛波醇酯活化阴性对照。

Packaging

玻璃安瓿封装。

Disclaimer

光敏性

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protein kinase C-mediated Ca2+ entry in HEK 293 cells transiently expressing human TRPV4.

Feng Xu et al.

British journal of pharmacology, 140(2), 413-421 (2003-09-13)

1. We investigated whether protein kinase C (PKC) activation stimulates Ca2+ entry in HEK 293 cells transfected with human TRPV4 cDNA and loaded with fura-2. 2. Phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester, increased the intracellular Ca2+ concentration ([Ca2+]i)

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

Gautam Bhave et al.

Proceedings of the National Academy of Sciences of the United States of America, 100(21), 12480-12485 (2003-10-03)

Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might

Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.

B L Van Duuren et al.

Cancer research, 39(7 Pt 1), 2644-2646 (1979-07-01)

4a alpha-Phorbol-9,9a-didecanoate, 4a alpha-phorbol-9-myristate-9a-acetate, and phorbol-9-myristate-9a-acetate-3-aldehyde were tested for skin tumor-promoting activity by using 7,12-dimethylbenz(a)anthracene as the initiating agent. There were 30 female ICR/Ha mice/group, and tests were continued for 434 to 461 days. 4a alpha-Phorbol-9,9a-didecanoate and 4a alpha-phorbol-9-myristate-9a-acetate were

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全球贸易项目编号

货号	GTIN
P148-1MG	04061834355052