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P1784

己酮可可碱

Name: 己酮可可碱
Brand: SIGMA

Phosphodiesterase inhibitor, solid

别名:

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₈N₄O₃

化学文摘社编号:

6493-05-6

分子量:

278.31

NACRES:

NA.77

PubChem Substance ID:

24278190

UNSPSC Code:

41106305

EC Number:

229-374-5

MDL number:

MFCD00063379

Form:

solid

Quality level:

100

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属性

产品名称

己酮可可碱, solid

form

solid

Quality Level

100

color

white

solubility

H₂O: ≥43 mg/mL, colorless to almost colorless

originator

Sanofi Aventis

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

Gene Information

human ... ADORA2B(136), LITAF(9516), PDE4B(5142), TNF(7124)
rat ... Tnf(24835)

说明

Application

Pentoxifylline has been used:

used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Biochem/physiol Actions

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H362

pcodes

P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Lact.

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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商品

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons

Donate-Correa J T, et al.

Journal of clinical medicine, 8(3), 287-287 (2019)

Pentoxifylline Enhances the Apoptotic Effect of Carboplatin in Y79 Retinoblastoma Cells

CRUZ-GALVEZ C C, et al.

In Vivo, 33(2), 401-412 (2019)

Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice

Naranjo T W, et al.

Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)

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全球贸易项目编号

货号	GTIN
P1784-100G	04061832899077
P1784-10G	04061834356745
P1784-250G	04061832899091