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P2443

Pluronic® F-127

powder, BioReagent, suitable for cell culture

别名:

Non-ionic copolymer surfactant

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关于此项目

线性分子式:
(C3H6O·C2H4O)x
化学文摘社编号:
9003-11-6
UNSPSC Code:
12161902
PubChem Substance ID:
24897874
NACRES:
NA.75
MDL number:
MFCD00082049
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Quality Level

200

description

Non-ionic, contains 100ppm BHT

product line

BioReagent

form

powder

mol wt

~12600 g/mol

technique(s)

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

transition temp

cloud point >100 °C

HLB

18 - 23

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

Pluronicpluronic® F-127，也称为泊洛沙姆 407，是一种无毒非离子共聚物。它含有以三嵌段结构排列的聚环氧乙烷-聚环氧丙烷，形成PEO-PPO-PEO对称。这种聚合物的表面活性剂特性来源于其两亲性，使它们能够与疏水表面和生物膜相互作用。

Application

Pluronic® F-127 已用于：

  • 作为肽到伤口部位的递送系统，以研究肽对小鼠伤口愈合的影响。
  • 作为 PDMS（聚二甲基硅氧烷）印章的表面涂层，使其具有水凝胶排斥性。
  • 制备用于测量神经活动的钙指示剂储备溶液。
  • 作为磷酸盐缓冲盐水 (PBS) 的成分，可降低非特异性细胞和蛋白质对基于 PDMS 的微流体装置的粘附。
  • 这种非离子共聚物表面活性剂适合作为消泡剂用于昆虫细胞培养应用。

Biochem/physiol Actions

Pluronic® F-127 是一种热可逆凝胶，由于其高热敏性、生物降解性和生物相容性而在不同行业中得到应用。这些特性使该聚合物适合用作多功能药物载体。Pluronic® F-127 通过提高药物的生物利用度和热稳定性来提高药物的治疗效果。此外，它还可以促进细胞附着和胶原蛋白形成，从而促进血管生成和组织再生。由于其功效，Pluronic F-127 已被用于间充质干细胞 (MSC) 的封装，以帮助血管水平低的组织再生，例如上皮组织、脂肪组织、软骨、肌腱和骨组织 。

Legal Information

Pluronic is a registered trademark of BASF

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCF5250
BCCF3046
0000149128
BCCG2429
BCCD0320

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全球贸易项目编号

货号GTIN
P2443-250G04061834363200
P2443-1KG04061835569076