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Merck
CN

P2772

L-α-磷脂酰胆碱

egg yolk, Type XI-E, 100 mg/mL in chloroform, ≥99%, solution

别名:

1,2-二酰基-sn-甘油-3-胆碱磷酸, 3-sn-磷脂酰胆碱, L-α-卵磷脂, Azolectin, PC

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关于此项目

化学文摘社编号:
UNSPSC Code:
51321705
NACRES:
NA.25
Beilstein/REAXYS Number:
5209585
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biological source

egg yolk

Quality Level

type

Type XI-E

assay

≥99%

form

solution

concentration

100 mg/mL in chloroform

functional group

phospholipid

lipid type

phosphoglycerides

storage temp.

−20°C

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

Application

<ul>
<li><strong>Fabrication of Microalgae Oil Vesicles for Drug Delivery Applications:</strong> This study highlights the use of L-a-Phosphatidylcholine in creating microalgae oil vesicles, showing promise for encapsulating and delivering hydrophobic drugs effectively (Lin YC et al., 2024).</li>
<li><strong>Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro:</strong> L-a-Phosphatidylcholine is employed to formulate terpene-modified lipid nanosystems, enhancing the solubility and bioactivity of temozolomide for glioblastoma treatment (Pashirova TN et al., 2023).</li>
<li><strong>Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases:</strong> Utilizing L-a-Phosphatidylcholine, this research developed mitochondria-targeted lipid nanoparticles, potentially offering a novel strategy for cancer therapy (Vasileva L et al., 2023).</li>
</ul>

Biochem/physiol Actions

脑磷脂脑中的主要结构磷脂,包含脂肪总量的约15%;主要局限于灰质。

Preparation Note

P2772 is supplied as a solution in chloroform. The same product is available as a lyophilized powder as Product No. P3556.


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

易制毒化学品(2类)
危险化学品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Alexander Vogel et al.
Biophysical journal, 107(1), 114-125 (2014-07-06)
Estradiol (E2) and E2 oleate associate with high-density lipoproteins (HDLs). Their orientation in HDLs is unknown. We studied the orientation of E2 and E2 oleate in membranes and reconstituted HDLs, finding that E2 and E2 oleate are membrane-associated and highly
V Künemund et al.
The Journal of cell biology, 106(1), 213-223 (1988-01-01)
We investigated whether the L2/HNK-1 carbohydrate epitope, expressed by two unusual glycolipids and several neural adhesion molecules, including L1, neural cell adhesion molecule, J1, and the myelin-associated glycoprotein, is involved in adhesion. Monoclonal L2 antibodies, the L2/HNK-1-reactive, sulfate-3-glucuronyl residue carrying
Daan Vorselen et al.
ACS nano, 11(3), 2628-2636 (2017-03-09)
Nanovesicles (∼100 nm) are ubiquitous in cell biology and an important vector for drug delivery. Mechanical properties of vesicles are known to influence cellular uptake, but the mechanism by which deformation dynamics affect internalization is poorly understood. This is partly



全球贸易项目编号

货号GTIN
P2772-250MG04061838066442
P2772-500MG04061834365235
P2772-100MG04061834365211
P2772-1G04061834365228