P2795
植物鞘氨醇盐酸盐 盐酸盐
别名:
4-羟基鞘氨醇, D-核糖-1,3,4-三羟基-2-十八胺, D-核糖-2-氨基十八-1,3,4-三醇, PHS
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关于此项目
经验公式（希尔记法）:
C18H39NO3 · HCl
化学文摘社编号:
分子量:
353.97
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
form
powder
Quality Level
greener alternative product score
old score: 19
new score: 9
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
greener alternative category
lipid type
sphingolipids
storage temp.
−20°C
SMILES string
Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
InChI
1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
InChI key
GDKAAHDFPOWGQE-RXQQAGQTSA-N
Biochem/physiol Actions
植物鞘氨醇是一种长链类鞘氨醇碱，广泛存在于酵母、植物和动物（包括哺乳动物）中。在酵母中，它可能通过激活 AGC 型蛋白激酶（Pkh1、Pkh2、Ypk1、Ypk2 和 Sch9）参与介导热应激反应。它在人类癌细胞系中具有促凋亡作用。PHS 直接或通过激活 p38MAPK 途径诱导 ΔΨm，并从线粒体释放细胞色素 c。这导致 caspase 9 激活，然后 caspase 3 激活和程序性细胞死亡。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Bing Yu et al.
American journal of epidemiology, 188(6), 991-1012 (2019-06-04)
The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprises 47 cohorts from Asia, Europe, North America, and South America
Amal M El-Naggar et al.
Cell death & disease, 10(1), 21-21 (2019-01-10)
Osteosarcoma is a malignant bone sarcoma characterized by extensive genomic disruption and a propensity for metastatic spread. Osteoid production suggests a close relationship with normal osteoblasts, and the latter are the presumptive cell of origin of this disease. The HACE1
Body Size Indicators and Risk of Gallbladder Cancer: Pooled Analysis of Individual-Level Data from 19 Prospective Cohort Studies.
Peter T Campbell et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 26(4), 597-606 (2017-03-21)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P2795-5MG | 04061834365242 |
| P2795-25MG | 04061833275818 |