产品名称
氧化苯胂, ≥97%, powder
biological source
synthetic (organic)
assay
≥97%
form
powder
color
white to off-white
mp
145-148 °C
solubility
DMSO: 50 mg/mL
SMILES string
O=[As]c1ccccc1
InChI
1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
InChI key
BQVCCPGCDUSGOE-UHFFFAOYSA-N
General description
苯氧化砷（PhAsO4）是一种双功能SH基化学物质。它本质上是疏水的。
Application
苯氧化砷已被用于通过黑质纹状体横断进行动物灌注，以确定过氧钒（pVa）是否会与脑源性神经营养因子（BDNF）协同作用。
Biochem/physiol Actions
苯氧化砷（PAO）可降低狗尾草的活力和可持续性。在EGTA（乙二醇-双（β-氨基乙基醚）N,N,N′,N′-）的存在下，它具有刺激环孢菌素A敏感型转化的能力。它可作为线粒体离子通量的一种刺激因子。
氧化苯胂可抑制细胞表面受体的内在化；抑制酪氨酸磷酸酶，且对酪氨酸激酶无影响。代谢毒物。
Features and Benefits
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study
Singh N, et al.
Acta Tropica, 159, 20-28 (2016)
Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
Lenartowicz E, et al.
Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats
Lu X, et al.
Experimental neurology, 178(2), 259-267 (2002)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P3075-1G | 04061834367147 |
| P3075-5G | 04061835558285 |