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P3371

五氟利多

Name: 五氟利多
Brand: SIGMA

≥97% (HPLC), powder

别名:

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

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关于此项目

经验公式（希尔记法）:

C₂₈H₂₇ClF₅NO

化学文摘社编号:

26864-56-2

分子量:

523.97

NACRES:

NA.77

PubChem Substance ID:

329820171

UNSPSC Code:

12352200

EC Number:

248-074-5

MDL number:

MFCD00866714

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

说明

Application

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells
to study its effects on the growth of glioblastoma cell lines,
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

T-type Ca²⁺channel blocker; antipsychotic

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Neuroleptic malignant syndrome associated with abrupt withdrawal of anticholinergic agents.

B Spivak et al.

International clinical psychopharmacology, 11(3), 207-209 (1996-09-01)

Neuroleptic malignant syndrome (NMS) is a severe side-effect of neuroleptic treatment. It is usually related to hypodopaminergic activity. A young schizophrenic patient who developed a typical episode of NMS during abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment is

Effects of the neuroprotectant lubeluzole on the cytotoxic actions of veratridine, barium, ouabain and 6-hydroxydopamine in chromaffin cells.

M F Cano-Abad et al.

British journal of pharmacology, 124(6), 1187-1196 (1998-08-28)

1. Incubation of bovine adrenal chromaffin cells with veratridine (10-100 microM) during 24 h, caused a concentration-dependent release of the cytosolic lactate dehydrogenase (LDH) into the bathing medium, an indicator of cell death. Lubeluzole or its R(-) enantiomer, R91154, did

Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.

M Mungthin et al.

The American journal of tropical medicine and hygiene, 60(3), 469-474 (1999-08-31)

The drug sensitivity characteristics and Plasmodium falciparum pfmdr1 status of five isolates of P. falciparum recently isolated from patients presenting for treatment from the Thailand/Myanmar border have been investigated. The aim of the study was to avoid the criticisms of

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全球贸易项目编号

货号	GTIN
P3371-50MG	04061834367765