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Merck
CN

P4651

异丙嗪 盐酸盐

histamine receptor antagonist, powder

别名:

10-(2-二甲基氨基-1-丙基)吩噻嗪 盐酸盐

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关于此项目

经验公式(希尔记法):
C17H20N2S · HCl
化学文摘社编号:
分子量:
320.88
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-375-2
MDL number:
Beilstein/REAXYS Number:
4166397
Form:
powder
Quality level:
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产品名称

异丙嗪 盐酸盐,

form

powder

Quality Level

originator

Wyeth

storage temp.

2-8°C

SMILES string

Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C

InChI

1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

InChI key

XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Biochem/physiol Actions

H 1 组胺受体拮抗剂;CNS 抑制剂;抗胆碱能药。

Features and Benefits

该化合物由 Wyeth 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里

Physical form

外观:白色或淡黄色,无味,结晶性粉末,缓慢氧化,长期暴露于空气中,呈蓝色。

Other Notes

溶解度:易溶于水、热无水乙醇和氯仿。几乎不溶于乙醚、丙酮和乙酸乙酯。


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signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Z Li et al.
Neuroscience, 70(1), 145-158 (1996-01-01)
Ionic mechanisms responsible for histamine-induced prolonged depolarization in supraoptic nucleus neurons were investigated using whole-cell patch recordings in horizontally prepared brain slices from adult male rats. Bath application of histamine (1-10 microM) in control medium induced membrane depolarization in nine
A B Wright et al.
Ultrasound in medicine & biology, 25(2), 241-247 (1999-05-13)
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in
Frank Fasbender et al.
Archives of toxicology, 94(2), 439-448 (2020-02-16)
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide expression



全球贸易项目编号

货号GTIN
P4651-100G04061834375005
P4651-25G04061834375012