P4875
D-青霉胺
98-101%
别名:
3,3-二甲基-D-半胱氨酸, 3-巯基-D-缬氨酸, D-(-)-2-氨基-3-巯基-3-甲基丁酸
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关于此项目
线性分子式:
(CH3)2C(SH)CH(NH2)CO2H
化学文摘社编号:
分子量:
149.21
UNSPSC Code:
51202303
NACRES:
NA.76
PubChem Substance ID:
EC Number:
200-148-8
Beilstein/REAXYS Number:
1722375
MDL number:
Quality Level
assay
98-101%
form
powder
mp
210 °C (dec.) (lit.)
solubility
H2O: 100 mg/mL
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
CC(C)(S)[C@@H](N)C(O)=O
InChI
1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
InChI key
VVNCNSJFMMFHPL-VKHMYHEASA-N
Gene Information
mouse ... Oprk1(18387)
General description
D-青霉胺来源于相应的 β-内酰胺抗生素的水解。
Application
在肝豆状核变性病中用作抗风湿药和螯合剂。用作铜螯合剂与半胱氨酸或其他硫化物介质组分形成混合二硫化物。用于灭活蛋白-1dna 结合 ，抑制兔关节软骨细胞异步培养的生长 。
Biochem/physiol Actions
青霉胺是青霉素类抗生素的特征性降解产物。一个铜原子与两个青霉胺分子结合。青霉胺可减少胱氨酸尿症中过量胱氨酸的排泄。这是通过青霉胺和胱氨酸之间的二硫键互换，形成易于排泄的青霉胺-半胱氨酸二硫化物。青霉胺可干扰原胶原分子之间交联的形成，并在新形成时将其裂解。青霉胺降低 IgM 类风湿因子，抑制 T 细胞活性。
Other Notes
将容器密闭保存在干燥和通风良好的地方。
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
Wenge Jiang et al.
Nature communications, 10(1), 2318-2318 (2019-05-28)
Since Pasteur first successfully separated right-handed and left-handed tartrate crystals in 1848, the understanding of how homochirality is achieved from enantiomeric mixtures has long been incomplete. Here, we report on a chirality dominance effect where organized, three-dimensional homochiral suprastructures of
M L Handel et al.
Molecular pharmacology, 50(3), 501-505 (1996-09-01)
D-Penicillamine (beta, beta-dimethyl cysteine) is an antirheumatic thiol drug with a poorly understood mechanism of action. On the basis that gold(I) thiolates and D-penicillamine are both capable of forming stable bonds with endogenous thiols, we sought a common target of
P Jaffray et al.
Annals of the rheumatic diseases, 43(2), 333-338 (1984-04-01)
The long-acting antirheumatic drug D-penicillamine was found to inhibit the growth of asynchronous cultures of rabbit articular chondrocytes. This inhibitory effect was dose-related between 5 X 10(-4) M and 5 X 10(-3) M and was time-dependent for a given dose.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P4875-1G | 04061834375296 |
| P4875-25G | 04061834375302 |
| P4875-5G | 04061834375319 |