P6374
p53 人
recombinant, expressed in baculovirus infected Sf21 cells
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关于此项目
NACRES:
NA.25
UNSPSC Code:
12352202
Form:
aqueous solution
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf21 cells
biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
assay
≥90% (SDS-PAGE)
form
aqueous solution
technique(s)
dot blot: suitable
UniProt accession no.
application(s)
genomic analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TP53(7157)
General description
p53 蛋白由一个具有反式激活结构域和富含脯氨酸结构域的 N 端结构域、一个中心核-DNA 结合结构域和一个具有四聚化和调节结构域的 C 端结构域组成。编码 p53 蛋白的 TP53 基因定位于人类染色体的 17p13.1上。
组氨酸标记的全长人 p53
Application
人p53 已用于斑点印迹。
可用于研究 p53 的翻译后修饰或蛋白质-蛋白质相互作用研究。
Biochem/physiol Actions
p53 蛋白作为一种转录因子参与正向或负向调节几个应答基因的表达。它在血管生成、细胞衰老、自噬、细胞存活、分化和氧化应激的调节中发挥作用。TP53 基因突变导致 Li Fraumeni 癌症综合征。
p53基因高度保守，在正常组织中表达。它是人类癌症中最常见的突变基因，研究人员已经描述了各种类型的恶性肿瘤、血液肿瘤和实体肿瘤中的500 多个基因突变。完整的 p53 功能对于维持细胞的非致瘤性表型至关重要。因此， p53在抑制癌症的发展中起着至关重要的作用。。
此外，最近的研究表明 p53 可诱导人胚胎干细胞的分化。该作用取决于 p53 的 DNA 结合活性。
Physical form
以溶于 20 mM Tris-HCl (pH 8.0)、10% 甘油、100 mM KCl、0.2 mM EDTA和 1 mM DTT 的溶液形式提供。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Se Kyung Lee et al.
PloS one, 10(8), e0124658-e0124658 (2015-08-05)
Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we
Abhinav K Jain et al.
PLoS biology, 10(2), e1001268-e1001268 (2012-03-06)
Multiple studies show that tumor suppressor p53 is a barrier to dedifferentiation; whether this is strictly due to repression of proliferation remains a subject of debate. Here, we show that p53 plays an active role in promoting differentiation of human
Alejandra Ward et al.
BMC cancer, 11, 71-71 (2011-02-18)
Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute to the development of HCC. We
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P6374-100UG | 04061833235232 |
| P6374-20UG | 04061838032485 |