P8511
反式 -2-苯环丙胺 盐酸盐
别名:
反苯环丙胺
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关于此项目
线性分子式:
C6H5C3H4NH2·HCl
化学文摘社编号:
分子量:
169.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥97% (TLC)
form
powder
mp
162-169 °C (lit.)
solubility
ethanol: 50 mg/mL, clear to slightly hazy
storage temp.
2-8°C
SMILES string
Cl.N[C@@H]1C[C@H]1c2ccccc2
InChI
1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
InChI key
ZPEFMSTTZXJOTM-OULXEKPRSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
Biochem/physiol Actions
非选择性 MAO-A/B 抑制剂。
Features and Benefits
该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
商品
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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Martin Engel et al.
Journal of neurochemistry, 149(4), 535-550 (2018-12-29)
Targeting epigenetic mechanisms has shown promise against several cancers but has so far been unsuccessful against glioblastoma (GBM). Altered histone 3 lysine 4 methylation and increased lysine-specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mechanisms
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P8511-250MG | 04061834401506 |
| P8511-1G | 04061826692332 |
| P8511-5G | 04061832948522 |