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P9053

2-吡啶醛肟甲氯

Name: 2-吡啶醛肟甲氯
Brand: SIGMA

别名:

2-PAM 氯化物, 氯解磷定

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关于此项目

经验公式（希尔记法）:

C₇H₉N₂O · Cl

化学文摘社编号:

51-15-0

分子量:

172.61

NACRES:

NA.77

PubChem Substance ID:

24899005

UNSPSC Code:

12352202

EC Number:

200-080-9

MDL number:

MFCD00011981

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属性

biological source

synthetic (organic)

Quality Level

100

form

solid

mp

230 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

SMILES string

[Cl-].C[n+]1ccccc1\C=N\O

InChI

1S/C7H8N2O.ClH/c1-9-5-3-2-4-7(9)6-8-10;/h2-6H,1H3;1H

InChI key

HIGSLXSBYYMVKI-UHFFFAOYSA-N

Gene Information

human ... ACHE(43)

说明

Biochem/physiol Actions

已被有机磷杀虫剂或神经毒剂灭活的乙酰胆碱酯酶的原型激活剂。现已知没有活化剂可对广谱的有机磷试剂有效。

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

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Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE).

Jyotiranjan Acharya et al.

European journal of medicinal chemistry, 46(9), 3926-3933 (2011-06-28)

A series of carbamoyl bis-pyridinium monooximes linked with xylene linker were synthesized and their in-vitro reactivation potential was evaluated against acetylcholinesterase (AChE) inhibited by organophosphorus inhibitors (OP) such as sarin, DFP and VX and the data were compared with reactivation

Quaternary salts of 4,3' and 4,4' bis-pyridinium monooximes. Part 2: synthesis and biological activity.

Chennamaneni Srinivas Rao et al.

Bioorganic & medicinal chemistry letters, 16(8), 2134-2138 (2006-02-17)

In continuation of our investigations of unsymmetrical bisquaternary monooximes, we synthesized four new series of compounds bridged by hexyl, heptyl, octyl and nonyl groups. All eight monooximes viz., dibromides of 1-(4-hydroxyiminomethylpyridinium)6-(3/4-carbamoylpyridinium)hexane, 1-(4-hydroxyiminomethylpyridinium)-7-(3/4-carbamoylpyridinium)heptane, 1-(4-hydroxyiminomethylpyridinium)-8-(3/4-carbamoylpyridinium)octane, 1-(4-hydroxyiminomethylpyridinium)-9-(3/4-carbamoylpyridinium)nonane as well as the corresponding bis-oximes

Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203).

Kamil Musilek et al.

Journal of medicinal chemistry, 50(22), 5514-5518 (2007-10-11)

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Among the organophosphates, with the exception of soman, tabun (GA) intoxications are the least responsive to treatment with commercially available therapeutics. A rational design was used to increase reactivation

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全球贸易项目编号

货号	GTIN
P9053-100G	04061832948546
P9053-25G	04061832948553
P9053-5G	04061834402237