主要文件

查看所有文档

P9115

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

Name: Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt
Brand: SIGMA

≥90% (HPLC), lyophilized powder

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₅₃H₉₈N₂₀O₁₂ · C₂HF₃O₂

分子量:

1321.50

NACRES:

NA.32

PubChem Substance ID:

329820342

UNSPSC Code:

12352204

MDL number:

MFCD03788010

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥90% (HPLC)

form

lyophilized powder

solubility

H₂O: soluble

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

InChI

1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1

InChI key

DBHNUJXUTKVLID-UXBYPZMDSA-N

Gene Information

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

说明

General description

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Biochem/physiol Actions

Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

The gene encoding the catalytic subunit Ca of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13. 1

Kjetil Tasken

Genomics, 36.3 , 535-538 (1996)

The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility.

Di Zazzo E

TheScientificWorldJournal, 565839-565839 (2014)

Long-term application of cannabinoids leads to dissociation between changes in cAMP and modulation of GABAA receptors of mouse trigeminal sensory neurons.

Laura Celotto et al.

Neurochemistry international, 126, 74-85 (2019-01-12)

Antinociception caused by cannabinoids may have a partial peripheral origin in addition to its central site of action. In fact, we have observed that anandamide selectively and reversibly inhibits GABAA receptors of putative nociceptive neurons of mouse trigeminal sensory ganglia

查看所有相关文献

全球贸易项目编号

货号	GTIN
P9115-1MG	04061834402305