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P9178

Prochlorperazine dimaleate salt

Name: Prochlorperazine dimaleate salt
Brand: SIGMA

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₄ClN₃S · 2C₄H₄O₄

化学文摘社编号:

84-02-6

分子量:

606.09

NACRES:

NA.77

PubChem Substance ID:

57654570

UNSPSC Code:

41116107

EC Number:

201-511-3

MDL number:

MFCD00069330

Form:

powder

Quality level:

200

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属性

form

powder

Quality Level

200

solubility

H₂O: slightly soluble 0.3 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.3 mg/mL, methanol: soluble

originator

GlaxoSmithKline

SMILES string

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1

InChI

1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

InChI key

DSKIOWHQLUWFLG-SPIKMXEPSA-N

Gene Information

human ... DRD2(1813)

说明

Biochem/physiol Actions

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulates sleep. Prochlorperazine is useful as a tranquilizer in the treatment of schizophrenia and nonpsychotic anxiety.

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; antispasmodic

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H336,H361d,H362

pcodes

P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Lact. - Repr. 2 - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

SLCD2523

050H0645

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Psychiatric Side Effects of Prescription and Over-the-counter Medications: Recognition and Management, 1946-1946 (1998)

Saunders Handbook of Veterinary Drugs - E-Book, 652-652 (2010)

Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors.

S C Lummis et al.

Neuropharmacology, 36(4-5), 665-670 (1997-04-01)

The effects of a range of phenothiazines were examined on 5-hydroxytryptamine3 (5-HT3) receptors in membranes from NIE-115 neuroblastoma cells using radioligand binding. Chlorpromazine, fluphenazine, perphenazine, trifluoperazine and prochlorperazine inhibited specific binding of both the 5-HT3 receptor antagonist [3H]GR65630 and agonist

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全球贸易项目编号

货号	GTIN
P9178-5G	04061832093024