P9405
O-磷酸- L -酪氨酸
≥95.0% (HPLC)
别名:
L -3-（4-羟基苯基）丙氨酸 4′-磷酸盐, L -酪氨酸-O-磷酸盐
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关于此项目
经验公式（希尔记法）:
C9H12NO6P
化学文摘社编号:
分子量:
261.17
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Beilstein/REAXYS Number:
3150815
MDL number:
产品名称
O-磷酸- L -酪氨酸,
assay
≥95.0% (HPLC)
Quality Level
form
powder
color
white to off-white
mp
225 °C
application(s)
cell analysis
storage temp.
−20°C
SMILES string
N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O
InChI
1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
InChI key
DCWXELXMIBXGTH-QMMMGPOBSA-N
Application
O-磷酸-L-酪氨酸已用于：
- 作为抗磷酸酪氨酸抗体的稀释剂，研究精子获能
- 在液相色谱-串联质谱(LC-MS-MS)分析中作为氨基酸标准品
- 作为氨基酸标准品在二维薄层电泳系统中分析磷酸化淀粉磷酸化酶(L-SP)上的磷酸化氨基酸
Biochem/physiol Actions
磷酸酪氨酸作为蛋白质调控的对接位点，通过刺激酪氨酸磷酸化蛋白与其他蛋白的磷酸酪氨酸结构域相互作用。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Chi Hoon Park et al.
BMC cancer, 16, 35-35 (2016-01-24)
c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer.
Julia Petschnigg et al.
Nature methods, 11(5), 585-592 (2014-03-25)
Cell signaling, one of key processes in both normal cellular function and disease, is coordinated by numerous interactions between membrane proteins that change in response to stimuli. We present a split ubiquitin-based method for detection of integral membrane protein-protein interactions
Jesse J Balic et al.
Cytokine, 92, 118-123 (2017-02-06)
Deregulated gp130-dependent STAT3 signalling by the pleiotropic cytokine interleukin (IL)-11 has been implicated in the pathogenesis of gastric cancer (GC), the third most common cancer worldwide. While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P9405-100MG | 04061834403067 |
| P9405-1G | 04061834403074 |
| P9405-250MG | 04061832418001 |