P9582
聚肌苷酸-聚胞苷酸 钾盐
10% Poly (I:C) with buffer salts, TLR ligand tested
别名:
Poly (I:C), Poly(I) • Poly(C)
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Assay:
≥99% (less than 1% free nucleotides, TLC)
Form:
lyophilized powder
Quality level:
Storage condition:
desiccated
Quality Level
assay
≥99% (less than 1% free nucleotides, TLC)
form
lyophilized powder
composition
Poly(I) • Poly(C), 10% (balance buffer salts as sodium chloride and sodium phosphate)
storage condition
desiccated
storage temp.
−20°C
Application
TLR3可识别双链RNA，是病毒病原体免疫应答的主要效应物。 聚肌苷酸-聚胞苷酸 (Poly(I) • Poly(C))是一种双链均聚物，可作为模型RNA，用于研究在TLR3水平下的细胞信号传导。 Poly(IC)是TRIF依赖型toll样受体3（TLR3）的配体。
Biochem/physiol Actions
将Poly(I:C)转染至NIT-1细胞中，已被用作细胞内dsRNA诱导的β细胞凋亡的模型。转染后18小时，45％的细胞发生凋亡，并且其NF-kB、p50/p65核转位、caspase 3和8切割以及caspase 12的转录诱导、Fas、IL-15和TNF受体相关配体（TRAIL）水平均增加。有人提出Poly(I:C)是最合适的稳定成熟树突状细胞（DC）诱导剂之一。这些成熟DC能够在CD40连接后分泌生物活性IL-12，因此注射后能够在体内产生有效的免疫应答。Poly(I:C)被用作有效的佐剂，以增强对肽类疫苗的特异性抗肿瘤免疫应答。
Packaging
包装规格取决于多核苷酸含量
Preparation Note
本品需要离子强度，以维持双链结构。用水复溶至浓度约为10 mg/mL，获得溶于生理磷酸盐缓冲溶液的多核苷酸。
Other Notes
双链均聚物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Marie Anaïs Labouesse et al.
Epigenetics, 10(12), 1143-1155 (2015-11-18)
Maternal infection during pregnancy increases the risk of neurodevelopmental disorders in the offspring. In addition to its influence on other neuronal systems, this early-life environmental adversity has been shown to negatively affect cortical γ-aminobutyric acid (GABA) functions in adult life
Wei-Li Wu et al.
Brain, behavior, and immunity, 62, 11-23 (2016-11-14)
Epidemiological studies show that maternal immune activation (MIA) during pregnancy is a risk factor for autism. However, mechanisms for how MIA affects brain development and behaviors in offspring remain poorly described. To determine whether placental interleukin-6 (IL-6) signaling is required
Halime Kalkavan et al.
Nature communications, 8, 14447-14447 (2017-03-02)
Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong and prolonged immune activation would represent a major immunotherapeutic advance. Here we show
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P9582-5MG | 04061838446565 |
| P9582-50MG | 04061834403999 |