PENNA
青霉素G 钠盐
~1650 U/mg
别名:
苄青霉素 钠盐
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关于此项目
经验公式（希尔记法）:
C16H17N2NaO4S
化学文摘社编号:
分子量:
356.37
UNSPSC Code:
51283424
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-710-2
Beilstein/REAXYS Number:
3834217
MDL number:
form
powder
Quality Level
specific activity
~1650 U/mg
solubility
H2O: 100 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
InChI
1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChI key
FCPVYOBCFFNJFS-LQDWTQKMSA-M
General description
Penicillin G is a narrow spectrum antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G contains β-lactam ring in their chemical structure.
Application
Penicillin G sodium salt has been used:
- to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility
- in cell culture alone as well as in combination with streptomycin and other antibiotics
- to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining
Biochem/physiol Actions
作用机制：青霉素G通过与青霉素结合蛋白(PBP)结合抑制肽聚糖链交联，从而抑制细胞壁合成。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
抗菌谱：本品具有抗革兰氏阳性菌和革兰氏阴性菌活性。
Packaging
1mu,10mu,100mu
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin
Disclaimer
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.
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signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
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商品
β-lactam antibacterials inhibit transpeptidase enzymes, preventing peptidoglycan assembly in both Gram-positive and Gram-negative bacteria.
J P Salanitro et al.
Applied and environmental microbiology, 32(4), 623-632 (1976-10-01)
Morphological and physiological studies were made on chicken cecal isolates of the strictly anaerobic bacterial species Gemmiger formicilis. Structural features (phase-contrast and electron microscopy) of these microorganisms indicate they (i) are highly pleomorphic, (ii) possess a trilaminar cell wall like
P Giesbrecht et al.
Journal of bacteriology, 174(7), 2241-2252 (1992-04-01)
Electron microscopic research into the murosomes of staphylococci has shown that the number of murosomes involved in penicillin-induced death varies depending on the experimental conditions employed. With 0.1 micrograms of penicillin G per ml, only 1 of a total of
Paul P Drury et al.
Neuropharmacology, 83, 62-70 (2014-04-15)
Basal ganglia injury after hypoxia-ischemia remains common in preterm infants, and is closely associated with later cerebral palsy. In the present study we tested the hypothesis that a highly selective neuronal nitric oxide synthase (nNOS) inhibitor, JI-10, would improve survival
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PENNA-100MU | 04061834413080 |
| PENNA-10MU | 04061835548170 |
| PENNA-1MU | 04061835548187 |