biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CASP1(834)
General description
半胱天冬酶-1也被称为白介素-1β转化酶(ICE)。它位于染色体11q22.2上。它有10个外显子、一个N端CARD(半胱天冬酶激活和募集结构域)、一个大P20亚基和一个小P10亚基。它存在于白细胞、单核细胞和上皮细胞中。
Immunogen
由人Caspase-1羧基末端附近的16个氨基酸组成的肽。
Application
家兔抗半胱天冬酶1 (ab1) 抗体可用于蛋白质印迹和免疫荧光。
Biochem/physiol Actions
Caspase-1可以将j促炎细胞因子白细胞介素-1β (IL-1β)和 IL-18转化为活性形式。 它参与细胞焦亡(pyroptosis)。它在冠状动脉粥样硬化患者的主动脉中过度表达。它通过诱导膜的生物发生来修复成孔毒素造成的损伤,从而有助于宿主细胞存活。
Physical form
溶剂为含有0.02%叠氮化钠的磷酸盐缓冲盐水
Other Notes
可以使用阻断肽 SBP3459阻断该抗体的作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1
Shamaa OR, et al.
PLoS ONE, 10(11) (2015)
Guibin Xu et al.
Aging, 8(5), 977-985 (2016-05-30)
Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the biogenesis and
CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))
Kumar Y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SBP3459-0.05MG | 04061832166032 |
| PRS3459-100UG | 04061836687045 |