PRS3463
Anti-Caspase-1 (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase), Anti-ICE, Anti-IL-1β converting enzyme
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
9
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CASP1(834)
General description
Caspase-1 is also known as interleukin-1βconverting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.
Immunogen
a 15 amino acid peptide from near the middle of human Caspase-1.
Biochem/physiol Actions
Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients.It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3463.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))
Kumar y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2008)
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
Paugh SW, et al.
Nature Genetics (2015)
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1
Shamaa OR, et al.
PLoS ONE, 10(11) (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SBP3463-0.05MG | 04061832166049 |
| PRS3463-100UG | 04061831489620 |