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Merck
CN

PRS4003

Anti-APH1 (ab2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-Anterior pharynx defective 1 homolog A (C. elegans), Anti-Presenilin stabilization factor

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
4
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 29 kDa

species reactivity

mouse, human, rat

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APH1A(51107)

General description

APH1 (anterior pharynx defective-1) is a component of γ-secretase complex. It is located on chromosome 1q21. It has 2 unique isoforms such as APH1a, located on chromosome 1 and APH1b, located on chromosome 15 (3).

Immunogen

a 18 amino acid peptide from near the center of human APH1.

Biochem/physiol Actions

APH1 (anterior pharynx defective-1) participates in the secretase like activity. Throughout the embryonic development, APH1 participates in presenilin dependent function.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4003.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience (2010)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience, 30(5), 1648-1656 (2010)
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
Pardossi-Piquard R, et al.
The Journal of Biological Chemistry, 284(24), 16298-16307 (2009)



全球贸易项目编号

货号GTIN
SBP4003-0.05MG04061832162911
PRS4003-100UG04061832509709