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Merck
CN

PZ0181

PD184352

≥98% (HPLC)

别名:

2-(2-氯-4-碘代苯氨基)-N-环丙基甲氧基-3,4-二氟苯甲酰胺, CI-1040

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关于此项目

经验公式(希尔记法):
C17H14ClF2IN2O2
化学文摘社编号:
分子量:
478.66
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥30 mg/mL

storage temp.

room temp

SMILES string

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Gene Information

Biochem/physiol Actions

PD184352(CI-1040)是 MEK(MKK1;MAPK 激酶)和密切相关的 MKK2 的高度选择性非竞争性抑制剂。它具有抗癌活性,抑制 ERK 通路,已与其他类型的抑制剂一起用于建立胚胎干细胞系。
PD184352(CI-1040)是一种高度选择性的 MEK(MKK1;MAPK 激酶)抑制剂。

Features and Benefits

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面,请点击此处


pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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PZ0181-5MG04061836687519
PZ0181-25MG04061832449227