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Q2128

使君子氨酸

Name: 使君子氨酸
Brand: SIGMA

L-glutamate agonist, powder

别名:

β-(3,5-二氧代-1,2,4-氧杂重氮烷-2-基)-L-丙氨酸

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关于此项目

经验公式（希尔记法）:

C₅H₇N₃O₅

化学文摘社编号:

52809-07-1

分子量:

189.13

NACRES:

NA.32

PubChem Substance ID:

24278004

UNSPSC Code:

12352106

MDL number:

MFCD00069337

Beilstein/REAXYS Number:

1078734

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属性

产品名称

使君子氨酸, powder

form

powder

Quality Level

200

color

white to off-white

solubility

ethanol: <0.17 mg/mL, H₂O: 0.5 mg/mL, 0.1 M HCl: 1.4 mg/mL, 1 M NH4OH: 20 mg/mL, organic solvents: insoluble

storage temp.

2-8°C

SMILES string

N[C@@H](CN1OC(=O)NC1=O)C(O)=O

InChI

1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1

InChI key

ASNFTDCKZKHJSW-REOHCLBHSA-N

Gene Information

rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418)

说明

General description

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Application

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

Biochem/physiol Actions

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null

Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.

Thibault Collin et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(29), 9281-9291 (2009-07-25)

Little is known about the generation of slow rhythms in brain neuronal circuits. Nevertheless, a few studies, both from reconstituted systems and from hippocampal slices, indicate that activation of metabotropic glutamate receptors (mGluRs) could generate such rhythms. Here we show

Reaction of endogenous progenitor cells in a rat model of posttraumatic syringomyelia.

Jian Tu et al.

Journal of neurosurgery. Spine, 14(5), 573-582 (2011-03-11)

Endogenous stem cells theoretically could replace lost tissue and repair deficits caused by syringes. In this study the authors quantitatively examined 1) whether neural progenitor cells exist in an adult rat model of posttraumatic syringomyelia (PTS); 2) and if so

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全球贸易项目编号

货号	GTIN
Q2128-5MG	04061833007983
Q2128-10MG	04061836687847
Q2128-1MG	04061826676721
Q2128-25MG	04061833007976