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关于此项目
经验公式(希尔记法):
C17H13N5
化学文摘社编号:
分子量:
287.32
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
RepSox, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
InChI
1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChI key
LBPKYPYHDKKRFS-UHFFFAOYSA-N
Application
RepSox已被用于转化生长因子β激酶1型受体(ALK5)的抑制剂。此外,还可用于基本培养基成分,以培养人类多能干细胞。
Biochem/physiol Actions
RepSox通过抑制SMAD族成员3 (Smad3)和c-Jun n -端激酶(JNK)途径/激活蛋白质1 (AP-1)途径,抑制破骨细胞分化、骨组织吸收和卵巢切除术(OVX)诱导的骨质疏松症(OP)。
RepSox 抑制 TGF-β 受体信号。
RepSox 抑制 TGF-β 受体信号。逆转录病毒转导 Sox2、Oct4 和 Klf4 基因导致体细胞直接重编程为诱导多能干细胞 (iPSC)。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors
Krentz N, et al.
Developmental Cell, 41(2), 129-142 (2017)
Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption
Mei L, et al.
Journal of Cellular Physiology, 233(12) (2018)
Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype
Hopkinson B, et al.
Testing, 8(6), 10580-10580 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R0158-25MG | 04061833221082 |
| R0158-5MG | 04061836693749 |