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关于此项目
经验公式(希尔记法):
C13H22N4O3S · HCl
化学文摘社编号:
分子量:
350.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
266-333-0
MDL number:
Form:
solid
Quality level:
产品名称
雷尼替丁 盐酸盐, solid
form
solid
Quality Level
color
tan
solubility
H2O: 1.8 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 7.0 mg/mL
originator
GlaxoSmithKline
SMILES string
Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
InChI
1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
InChI key
GGWBHVILAJZWKJ-CHHCPSLASA-N
Gene Information
human ... HRH2(3274)
Application
盐酸雷尼替丁已被用作开发和验证平行人工膜渗透性试验 (PAMPA) 的参考化合物。
Biochem/physiol Actions
雷尼替丁主要用于治疗非甾体类抗炎药 (NSAID) 引起的胃肠道损害。
H2 组胺受体拮抗剂;抗溃疡剂。
Features and Benefits
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
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Explore all of our products under 雷尼替丁 盐酸盐
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Discover Bioactive Small Molecules for ADME/Tox
Ranitidine
Grant S M, et al.
Drugs, 37(6), 801-870 (1989)
Ying Liu et al.
Molecular and cellular biochemistry, 448(1-2), 61-69 (2018-02-07)
Abnormal angiogenesis is critically involved in tumor progression and metastasis including endometrial cancer and is regulated by microRNAs such as microRNA-101 (miR-101). We hypothesize that miR-101 expression is disrupted in endometrial cancer and modulation of miR-101 levels is sufficient to
P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R101-5G | 04061836694135 |
| R101-1G | 04061836694128 |

