R121
S(−)-雷氯必利 (+)-酒石酸盐
>97%, Dopamine D2 receptor antagonist, solid
别名:
3,5-二氯-N-（1-乙基吡咯烷-2-基甲基）-2-羟基-6-甲氧基苯甲酰胺 (+)-酒石酸盐
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关于此项目
经验公式（希尔记法）:
C15H20Cl2N2O3 · C4H6O6
化学文摘社编号:
分子量:
497.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
S(−)-雷氯必利 (+)-酒石酸盐, >97%, solid
Quality Level
assay
>97%
form
solid
color
white
solubility
H2O: 89 mg/mL
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
InChI
1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
InChI key
QULBVRZTKPQGCR-NDAAPVSOSA-N
Gene Information
human ... DRD2(1813)
Application
S(−)-雷氯必利(+)-酒石酸盐已用作D2 受体拮抗剂：
- 研究D2受体在介导动物PAG腹外侧区(vlPAG)/背侧中缝多巴胺能镇痛中的作用
- Thap1缺失小鼠药理学和行为研究
- 测定Ca2+瞬变与大鼠多巴胺神经元活性之间的关系
Biochem/physiol Actions
雷氯必利是一种苯甲酰胺衍生物和选择性D2多巴胺受体拮抗剂。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Disclaimer
光敏性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
P Protais et al.
European journal of pharmacology, 271(1), 167-177 (1994-12-12)
S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some behavioural models able to characterize dopamine antagonist properties. In mice treated with apomorphine (0.75 mg/kg, s.c.), stereotyped climbing and sniffing were dose dependently antagonized by
J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R121-100MG | 04061832093147 |
| R121-25MG | 04061836694272 |