R4408
氯霉素
Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), ≥98% (HPLC)
别名:
D-(-)-苏-2,2-二氯-N-[β-羟基-α−（羟甲基）-β-（4-硝基苯基）乙基]乙酰胺, D-(-)-苏-2-二氯乙酰胺基-1-（4-硝基苯基）-1,3-丙二醇, D-苏-2,2-二氯-N-[β-羟基-α-（羟甲基）-4-硝基苯乙基]乙酰胺
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关于此项目
NACRES:
NA.85
UNSPSC Code:
51102831
Quality Level
assay
≥98% (HPLC)
form
ready-to-use solution
concentration
100 mg/mL in ethanol: isopropanol (95:5)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
Application
氯霉素是一种合成抗生素，从委内瑞拉链霉菌菌株中分离出来。 它通常以10-20 μg/mL的浓度用于分子生物学应用中的细菌选择，并作为含有氯霉素抗性基因的转化细胞的选择剂。
Biochem/physiol Actions
作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
Packaging
10ml
Preparation Note
该产品是在乙醇：异丙醇（95:5）中制备的100 mg/mL溶液。 干冰运输，-20℃下保存。
Other Notes
保存于密闭容器内，置于干燥通风处。打开的容器必须小心地重新密封，并保持直立以防止泄漏。储存等级（TRGS 510）：易燃液体“）
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
57.2 °F - closed cup
flash_point_c
14.0 °C - closed cup
法规信息
危险化学品
此项目有
Young Chan Song et al.
Annals of dermatology, 23(3), 321-328 (2011-09-13)
Although acne is a common follicular inflammatory dermatosis, studies of the relationship between Malassezia yeasts and acne have rarely been conducted. We sought to identify Malassezia yeasts from acne patients and establish a relationship between specific types of species of
Volkmar Passoth et al.
Biotechnology for biofuels, 2(1), 16-16 (2009-08-22)
Drying is currently the most frequently used conservation method for cereal grain, which in temperate climates consumes a major part of process energy. Airtight storage of moist feed grain using the biocontrol yeast Pichia anomala as biopreservation agent can substantially
Stephanie Petrella et al.
Antimicrobial agents and chemotherapy, 52(10), 3725-3736 (2008-07-16)
Two clinical strains of Escherichia coli (2138) and Enterobacter cloacae (7506) isolated from the same patient in France and showing resistance to extended-spectrum cephalosporins and low susceptibility to imipenem were investigated. Both strains harbored the plasmid-contained bla(TEM-1) and bla(KPC-2) genes.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R4408-10ML | 04061836695309 |