Monoclonal Anti-RANTES antibody produced in rat

purified, E. coli-derived, recombinant mouse RANTES.

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.

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