S0447
SIS3
≥98% (HPLC), TGF-β1/ALK-5 phosphorylation inhibitor, powder
别名:
(2E)-1-(6,7-二甲氧基-3,4-二氢-1H-异喹啉-2-基)-3-(1-甲基-2-苯基-1H-吡咯并[2,3-b]吡啶吡啶-3-基)-丙烯酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C28H27N3O3 · HCl
化学文摘社编号:
分子量:
489.99
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SIS3, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
H2O: <2 mg/mL, DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key
CDKIEBFIMCSCBB-CALJPSDSSA-N
Application
Sugar insensitive 3 (SIS3) 已被用作各种细胞中的samd3抑制剂。
Biochem/physiol Actions
Sugar insensitive 3 (SIS3) 促进药物引起的细胞凋亡，并阻碍三磷酸腺苷（ATP）结合盒（ABC）转运蛋白 (ABCB1) 和ABCG2发挥功能。它使在癌细胞中过度表达的ABCB1 和 ABCG2再次敏化，这有助于化疗。
SIS3 是一种 TGF-β1/ALK-5磷酸化 Smad3 的新型特异性抑制剂
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes?But without modulating bone morphogenetic protein 7 signaling
Gressner OA, et al.
Hepatology, 49(6), 2021-2030 (2009)
Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells
Tovar-Vidales T, et al.
Experimental Eye Research, 93(4), 442-451 (2011)
The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
Tang PMK, et al.
Kidney International, 93(1), 173-187 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S0447-5MG | 04061836830274 |