Anti-Somatostatin Receptor Type 1 antibody produced in rabbit

Somatostatin Receptor Type 1 (SSTR1) is present in blood vessels, neuroendocrine cells, and the retina. SSTR1 gene is mapped to human chromosome 14q21.1.

synthetic peptide corresponding to the C-terminal of human somatostatin receptor type 1, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Somatostatin Receptor Type 1 (SSTR1) protein extracellular loop regions are crucial for ligand binding. SSTR1 gene down-regulated in reported in preeclampsia but it is overexpressed in breast cancer. It is reported to block the mitogen-activated protein kinase (MAPK) pathway. However, in pancreatic cell lines, elevated expression of SSTR1 gene favors cell cycle arrest. SSTR1 also plays a tumor suppressor role in gastric cancer invasion.

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

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