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S153

SQ 22536

Name: SQ 22536
Brand: SIGMA

≥97% (HPLC), Adenylate cyclase inhibitor, powder

别名:

9-THF-Ade, 9-（四氢-2-呋喃基）-9H-嘌呤-6-胺

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关于此项目

经验公式（希尔记法）:

C₉H₁₁N₅O

化学文摘社编号:

17318-31-9

分子量:

205.22

UNSPSC Code:

41106305

PubChem Substance ID:

24278057

NACRES:

NA.77

MDL number:

MFCD00210216

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

SQ 22,536, ≥97% (HPLC), powder

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL, H₂O: insoluble

SMILES string

Nc1ncnc2n(cnc12)C3CCCO3

InChI

1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)

InChI key

UKHMZCMKHPHFOT-UHFFFAOYSA-N

Gene Information

human ... ADCY1(107), ADCY2(108), ADCY3(109), ADCY4(196883), ADCY5(111), ADCY6(112), ADCY7(113), ADCY8(114), ADCY9(115)
rat ... Adora1(29290), Adora2a(25369)

说明

Application

SQ 22,536已被用于研究腺苷酸环化酶在PC12细胞分化和乳腺癌细胞中的间隙连接细胞间通讯中的作用。

Biochem/physiol Actions

SQ 22,536不仅是血小板中基础腺苷酸环化酶，也是前列腺素E1激活的腺苷酸环化酶活性的有效抑制剂。¹ 当对大鼠进行肌肉注射时，它可以对侧和同侧逆转痛觉过敏。²

SQ 22,536是一种细胞可渗透的腺苷酸环化酶抑制剂。在去污剂剂分散的大鼠脑制剂中，IC₅₀ = 20 μM。

Features and Benefits

该化合物是受体分类及信号转导手册上腺苷酸环化酶页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

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Molecular cancer research : MCR, 6(6), 1003-1016 (2008-06-24)

Although prostaglandin E2 (PGE2) has been shown by pharmacologic and genetic studies to be important in skin cancer, the molecular mechanism(s) by which it contributes to tumor growth is not well understood. In this study, we investigated the mechanisms by

Effects of polybrominated diphenyl ethers on steroidogenesis in rat Leydig cells.

Kai-Lee Wang et al.

Human reproduction (Oxford, England), 26(8), 2209-2217 (2011-06-07)

Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that have been defined as major environmental pollutants. While previous studies have found that PBDEs may enhance the levels of sex-steroid hormones, their effects on testosterone secretion from rat Leydig cells are

Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536.

C Lippe et al.

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 99(1-2), 209-211 (1991-01-01)

1. The effects of both adenyl cyclase inhibitors (MDL12330A and SQ22536) have been studied on the ionic transport induced by vasopressin and isoprenaline across the frog skin. 2. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC), confirming that

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