S166
Saclofen
solid
别名:
β-（氨甲基）-4-氯苯乙磺酸
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关于此项目
经验公式（希尔记法）:
C9H12ClNO3S
化学文摘社编号:
分子量:
249.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
0.1 M NaOH: 20 mg/mL
SMILES string
NCC(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChI key
JYLNVJYYQQXNEK-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)
Application
使用Saclofen作为GABAB受体拮抗剂以研究大鼠反复注射羟考酮的镇痛作用。
Saclofen已被用于阻止催产素对辣椒素诱导的谷氨酸自发兴奋性传递的抑制作用。
Biochem/physiol Actions
Saclofen是巴氯芬的磺酸类似物，是一种选择性GABAB受体拮抗剂。
Saclofen可能具有交感神经系统依赖性抗炎作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
David P Archer et al.
Anesthesia and analgesia, 104(4), 840-846 (2007-03-23)
Synaptic plasticity is thought to provide a molecular mechanism for learning and memory. N-methyl-d-aspartate receptor-mediated plasticity requires that N-methyl-d-aspartate receptor activation coincides with postsynaptic depolarizing potentials (DPSP(A)'s). Pentobarbital, in high concentrations, enhances DPSP(A)'s, but high concentrations suppress synaptic plasticity, probably
D I Kerr et al.
Neuroscience letters, 107(1-3), 239-244 (1989-12-15)
Saclofen (the direct sulphonic analogue of baclofen) is a competitive antagonist of baclofen at GABAB receptors in guinea pig ileum and rat cortical slices (estimated pA2 = 5.3), at least twice as potent as 2-hydroxy-saclofen (pA2 = 5). A series
Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA
David I.B.Kerr
Neuroscience Letters (1989)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB5701894-100UL | 04065267678719 |
| SAB5700317-100UL | 04065265172622 |
| SAB5701958-100UL | 04065267679358 |
| S166-5MG | 04061836912925 |