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S2816

SKF-83959 hydrobromide

Name: SKF-83959 hydrobromide
Brand: SIGMA

≥98% (HPLC), solid

别名:

6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₀NClO₂ · HBr

化学文摘社编号:

80751-85-5

分子量:

398.72

NACRES:

NA.77

PubChem Substance ID:

24278699

UNSPSC Code:

12352200

MDL number:

MFCD03792727

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

SMILES string

Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3

InChI

1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H

InChI key

FHYWNBUFNGHNCP-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

说明

Application

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Biochem/physiol Actions

D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D(1) dopamine receptor agonist SKF 83959.

Katsunori Tomiyama et al.

Synapse (New York, N.Y.), 64(9), 714-720 (2010-03-27)

Orofacial movements are regulated by D(1)-like dopamine receptors interacting with additional mechanisms. Phospholipase C-related catalytically inactive protein (PRIP) regulates cell surface expression of GABA(A) receptors containing a gamma2 subunit. Mutant mice with double knockout of PRIP-1 and PRIP-2 were used

Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses.

Jue Liu et al.

Neuropharmacology, 57(2), 164-171 (2009-05-26)

Recent work has demonstrated that a phosphatidylinositol (PI)-linked D(1) dopamine receptor selective agonist, SKF83959, mediates phosphatidylinositol hydrolysis via activation of phospholipase C(beta) in brain. Specific contributions of SKF83959 to synaptic plasticity have not been well elucidated. The aim of the

Ling Zhang et al.

Neurochemistry international, 58(3), 281-294 (2010-12-08)

Accumulating pathological evidence showing layer-specific neuronal reduction, dendrite deficits and brain volume loss have implicated an apoptotic process in schizophrenia, but the exact mechanism remains elusive. Dopamine hyperactivity at D2 receptor sites was considered as an important mechanism in schizophrenia

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全球贸易项目编号

货号	GTIN
S2816-25MG	04061832093475
S2816-5MG	04061832093482