S3442
SB 216763
>98% (HPLC), glycogen synthase kinase-3 inhibitor
别名:
3-（2,4-二氯苯基）-4-（1-甲基-1H-吲哚-3-基）-1H-吡咯-2,5-二酮
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关于此项目
经验公式（希尔记法）:
C19H12N2O2Cl2
化学文摘社编号:
分子量:
371.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
>98% (HPLC)
Quality level:
产品名称
SB 216763, >98% (HPLC)
Quality Level
assay
>98% (HPLC)
color
orange
solubility
DMSO: soluble 20 mg/mL, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
InChI
1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChI key
JCSGFHVFHSKIJH-UHFFFAOYSA-N
Gene Information
human ... GSK3A(2931), GSK3B(2932)
Application
使用 SB-216763 抑制人脑微血管内皮细胞系 和大肠癌细胞中的 GSK-3β。
Biochem/physiol Actions
SB-216763 是一种与 ATP 竞争并强效抑制 α和 βGSK-3 的同工酶。作为神经保护剂，它防止 PI3-激酶途径诱导的神经细胞死亡。它还可以延迟预处理，减少梗死面积，防止心肌缺血。
强效、选择性、细胞渗透性糖原合成酶激酶-3 (GSK-3) 抑制剂。
Features and Benefits
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。前往 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。
该化合物由 GlaxoSmithKline 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
Legal Information
根据GlaxoSmithKline的协议出售用于研究目的
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
D A Cross et al.
Journal of neurochemistry, 77(1), 94-102 (2001-03-30)
The phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (PKB; also known as Akt) signalling pathway is recognized as playing a central role in the survival of diverse cell types. Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine protein kinase that
Xiangdang Shi et al.
Psychopharmacology, 231(16), 3109-3118 (2014-03-07)
Memories return to a labile state following their retrieval and must undergo a process of reconsolidation to be maintained. Thus, disruption of cocaine reward memories by interference with reconsolidation may be therapeutically beneficial in the treatment of cocaine addiction. The
Shuzhen Guo et al.
Stroke, 40(2), 652-655 (2008-11-01)
We recently reported that delayed lithium therapy can improve stroke recovery in rats by augmenting neurovascular remodeling. We tested the hypothesis that lithium can promote the expression of growth factors in brain endothelial cells and astrocytes. Human brain microvascular endothelial
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S3442-25MG | 04061832449661 |
| S3442-5MG | 04061836922849 |