biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~28 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable, western blot: 2.5-5 μg/mL using human HepG2 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SIRT3(23410)
General description
Sirtuin 3(Sirt3)是定位于线粒体基质的NAD依赖性脱乙酰基酶。SIRT3编码一个44 kDa的全长形式和一个N端142个氨基酸的截短形式。它位于人染色体11p15.5。
Immunogen
对应于人SIRT3第384-399个氨基酸的合成肽,通过N-末端的半胱氨酸残基与KLH发生偶联。
Application
兔抗Sirt3抗体还可用于蛋白质印迹。
Biochem/physiol Actions
Sirtuin 3(Sirt3)主要是一种核蛋白,在细胞应激期间转移到线粒体中。在人类中,Sirt3脱乙酰基并激活线粒体酶乙酰辅酶A合成酶1(AceCS2)。Sirt3与调节棕色脂肪细胞的线粒体功能和生热有关。已证明其水平与延长寿命相关。Sirt3水平升高与淋巴结阳性乳腺癌有关。
Physical form
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
SIRT2 promotes the migration and invasion of gastric cancer through RAS/ERK/JNK/MMP-9 pathway by increasing PEPCK1-related metabolism
Li Y, et al.
Neoplasia, 20(7), 745-756 (2018)
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
Scher MB, et al.
Genes & Development, 21(8), 920-928 (2007)
Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13
Bellizzi D, et al.
Genomics, 89(1), 143-150 (2007)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S4072-200UL | 04061837795121 |