S4503
DL-丝氨酸异羟肟酸酯
≥97% (TLC), suitable for ligand binding assays
别名:
SHX
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关于此项目
经验公式（希尔记法）:
C3H8N2O3
化学文摘社编号:
分子量:
120.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
DL-丝氨酸异羟肟酸酯, seryl-tRNA synthetase inhibitor
Quality Level
assay
≥97% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white to off-white
application(s)
cell analysis
storage temp.
−20°C
SMILES string
NC(CO)C(=O)NO
InChI
1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
InChI key
LELJBJGDDGUFRP-UHFFFAOYSA-N
Application
丝氨酸已被用作丝氨酰-tRNA 合成酶的抑制剂。 DL-丝氨酸异羟肟酸用于通过氨基酸饥饿诱导大肠杆菌中鸟苷 3′-二磷酸5′-二磷酸（ppGpp）的代谢合成。它还用于通过抑制 tRNA 装载来同步大肠杆菌培养物中的细胞周期。
Biochem/physiol Actions
丝氨酸参与单碳单位代谢。它与半胱氨酸、神经酰胺、磷脂酰丝氨酸、嘌呤和嘧啶的生物合成有关。在细菌中，它参与色氨酸合成。糖异生是重要的生化过程之一，涉及丝氨酸，尤其在反刍动物中。蛋白质磷酸化是利用丝氨酸的一种此类事件。甘氨酸是丝氨酸的代谢产物，可作为抗氧化剂和神经递质。已知 D-丝氨酸激活脑的 N-甲基-D-天冬氨酸（NMDA）受体。丝氨酸异羟肟酸，一种丝氨酸的结构类似物，它可阻止丝氨酸-tRNA（转移核糖核酸）装载，从而降低大肠杆菌的磷脂和核酸合成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Olaf Brockmann-Gretza et al.
BMC genomics, 7, 230-230 (2006-09-12)
The stringent response is the initial reaction of microorganisms to nutritional stress. During stringent response the small nucleotides (p)ppGpp act as global regulators and reprogram bacterial transcription. In this work, the genetic network controlled by the stringent response was characterized
Dao Nguyen et al.
Science (New York, N.Y.), 334(6058), 982-986 (2011-11-19)
Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of antibiotic targets caused by starvation-induced growth arrest is thought to be a key mechanism producing tolerance. Here we show that the antibiotic tolerance of nutrient-limited and biofilm
H J Cha et al.
Applied and environmental microbiology, 65(2), 409-414 (1999-01-30)
We constructed and characterized three stress probe plasmids which utilize a green fluorescent protein as a noninvasive reporter in order to elucidate Escherichia coli cellular stress responses in quiescent or resting cells. Cellular stress levels were easily detected by fusing
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S4503-1G | 04061826214497 |
| S4503-250MG | 04061836927004 |