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Merck
CN

S5637

磺胺二甲基嘧啶 钠盐

≥98%

别名:

4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺

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关于此项目

线性分子式:
C12H13N4O2SNa
化学文摘社编号:
分子量:
300.31
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51284910
EC Number:
217-840-0
MDL number:
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Quality Level

assay

≥98%

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to off-white

solubility

H2O: soluble 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

DNA synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

[Na].Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

InChI

1S/C12H14N4O2S.Na.H/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11;;/h3-7H,13H2,1-2H3,(H,14,15,16);;

InChI key

WIVZAHIZHZEEOX-UHFFFAOYSA-N

General description

化学结构:磺胺

Application

磺胺二甲嘧啶是一种抗生素,在临床上用于治疗支气管炎、前列腺炎和尿路感染。用于处置和消除动力学研究。其用于开发液体(如牛奶、蜂蜜和猪尿)中的定量检测技术

Biochem/physiol Actions

磺胺二甲嘧啶是一种抗微生物性硫药,通过抑制二氢喋呤合成酶而阻断二氢叶酸的合成。磺胺二甲嘧啶是细菌合成叶酸所需的对氨基苯甲酸 (PABA) 的竞争性抑制剂。诱导 CYP3A4 表达并被 N-乙酰转移酶乙酰化。它表现出性别依赖性药代动力学,由男性特有的 CYP2C11 亚型代谢。磺胺二甲嘧啶具有抑菌作用。

Packaging

25G,100G

Other Notes

保存于密闭容器内,置于干燥通风处。


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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C J Chapron et al.
Journal of clinical pharmacology, 16(7), 338-344 (1976-07-01)
The relationship between sulfamethazine disposition kinetics and acetylation phenotype was studied in man. Sulfamethazine pharmacokinetic parameters were determined after the administration of the drug as an oral suspension. When the half-life, acetylation rate constant, or per cent available dose excreted
A D Mitchell et al.
Drug metabolism and disposition: the biological fate of chemicals, 14(2), 161-165 (1986-03-01)
Swine weighing 60-70 kg were orally administered 14C-sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzene[U-14C]sulfonamide] at 12-hr intervals for 7 days (165 mg/dose; 0.126-5.04 mCi/mmol). The animals were sacrificed at 8 hr or 2, 5, or 10 days after the last dose was given and tissues
Tangbin Yang et al.
Hybridoma (2005), 29(5), 403-407 (2010-11-06)
A specific monoclonal antibody (MAb) against sulfamethazine was produced with hybridoma technology. This assay shows very high sensitivity with IC50 of 0.4 ng/mL and LOD of 0.05 ng/mL when it was run in 0.02 mol/L PBS (pH 7.5). This MAb has shown high



全球贸易项目编号

货号GTIN
S5637-25G04061836954673
S5637-100G04061836954666