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S7049

D-鞘氨醇

Name: <SC>D</SC>-鞘氨醇
Brand: SIGMA

synthetic

别名:

4-鞘氨醇, 反式-D-赤-2-氨基-4-十八烯-1，3-二醇, （2S，3R，4E）-2-氨基-4-十八烯-1，3-二醇

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关于此项目

经验公式（希尔记法）:

C₁₈H₃₇NO₂

化学文摘社编号:

123-78-4

分子量:

299.49

UNSPSC Code:

12352211

NACRES:

NA.77

PubChem Substance ID:

24899729

EC Number:

204-651-3

Beilstein/REAXYS Number:

1727294

MDL number:

MFCD00036751

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属性

biological source

synthetic

Quality Level

100

assay

≥98% (TLC)

form

powder

mp

74.2-78.1 °C

solubility

chloroform: complete 20 mg/mL, clear, colorless

lipid type

sphingolipids

storage temp.

−20°C

SMILES string

OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1

InChI key

WWUZIQQURGPMPG-KRWOKUGFSA-N

Gene Information

rat ... Prkca(24680)

说明

Application

已研究了 D-Sphingosine（合成的）对真菌莱氏野村菌的发芽活性的影响。⁸

Biochem/physiol Actions

细胞膜的一种组成部分。神经酰胺的前体。蛋白激酶 C 的选择性抑制剂，但不抑制蛋白激酶 A 或肌球蛋白轻链激酶。钙调蛋白依赖性酶的抑制剂。

鞘氨醇的天然异构体

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hcodes

H413

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 4

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Epidermal growth factor receptor defects in leprechaunism. A multiple growth factor-resistant syndrome.

S S Reddy et al.

The Journal of clinical investigation, 84(5), 1569-1576 (1989-11-01)

Leprechaunism is a rare genetic disorder characterized by severe growth retardation and insulin resistance. Maximal epidermal growth factor (EGF) binding was reduced in fibroblasts from three unrelated patients with leprechaunism (Ark-1, Can-1, and Minn-1) compared with control (0.8-2.2%/mg protein vs.

Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.

Tim Ting Chiu et al.

The Journal of biological chemistry, 288(24), 17520-17531 (2013-05-04)

Insulin activates a cascade of signaling molecules, including Rac-1, Akt, and AS160, to promote the net gain of glucose transporter 4 (GLUT4) at the plasma membrane of muscle cells. Interestingly, constitutively active Rac-1 expression results in a hormone-independent increase in

Basis for fluctuations in lymphocyte counts in fingolimod-treated patients with multiple sclerosis.

David Henault et al.

Neurology, 81(20), 1768-1772 (2013-10-18)

To determine the range of fluctuation in total lymphocyte counts (TLCs) in peripheral blood over a 4- to 7-year period in patients with MS receiving fingolimod (FTY720) and the relation between TLCs and T-cell subsets (CD4+, CD8+, CCR7+/-) that are

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全球贸易项目编号

货号	GTIN
S7049-25MG	04061833276105
S7049-5MG	04061836959760

主要文件

D-鞘氨醇

synthetic

选择尺寸

关于此项目

biological source

Quality Level

assay

form

mp

solubility

lipid type

storage temp.

SMILES string

InChI

InChI key

Gene Information

Application

Biochem/physiol Actions

Still not finding the right product?

安全信息

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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