S7067
SB 202190
≥98% (HPLC), powder, p38 MAP kinase inhibitor
别名:
4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑
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关于此项目
经验公式（希尔记法）:
C20H14FN3O
化学文摘社编号:
分子量:
331.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SB 202190, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
faintly yellow, to beige
solubility
DMSO: 10 mg/mL, clear
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
Gene Information
human ... MAPK14(1432)
General description
SB202190可增强NPC1缺陷小鼠神经干细胞的自我更新能力。
Application
SB 202190用于：
- 研究p38丝裂原活化蛋白激酶(MAPK)信号传导对于实现呼肠孤病毒感染的作用
- 作为p38α抑制剂，体内研究其对APC Min/+ 小鼠结肠粘膜组织中腺癌发生发展或进展的作用。
- 作为基底细胞基础培养基组分，培养基底祖细胞。
- 作为正常内膜和内膜肿瘤培养基用于类器官培养。
SB 202190被用于抑制MCF7细胞5、小鼠巨噬细胞6和HepG2细胞的p38活化。7
Biochem/physiol Actions
SB 202190是p38 MAP激酶的高选择性、有效的和细胞渗透性抑制剂。SB 202190在活性激酶的ATP口袋内结合（Kd = 38nM，在重组人p38中测量得到），并选择性抑制p38α和β亚型。
Features and Benefits
该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
Legal Information
根据GlaxoSmithKline协议出售，用于研究目的
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存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
C J Chang et al.
European journal of clinical investigation, 36(8), 588-596 (2006-08-09)
The molecular mechanisms underlying the mitogenic effect of ferulic acid (FA), an active compound derived from Angelica sinensis, have never been elucidated. It was the aim of this study to investigate the proliferative effect of FA on human breast cancer
Carissa C James et al.
Molecular biology of the cell (2018-02-23)
Epithelial-mesenchymal transition (EMT) is activated during development, wound healing, and pathologies including fibrosis and cancer metastasis. Hallmarks of EMT are remodeling of intercellular junctions and adhesion proteins, including gap junctions. The GJA1 mRNA transcript encoding the gap junction protein connexin43
Lívia das Graças Amaral Avelar et al.
Frontiers in immunology, 10, 21-21 (2019-02-09)
Eukaryotic protein kinases (ePKs) are good medical targets for drug development in different biological systems. ePKs participate in many cellular processes, including the p38 MAPK regulation of homeostasis upon oxidative stress. We propose to assess the role of Smp38 MAPK
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S7067-5MG | 04061836959784 |
| S7067-25MG | 04061836959777 |