S7947
Stattic
≥98% (HPLC), STAT3 activation inhibitor, powder
别名:
6-硝基苯并[b] 噻吩-1,1-二氧化物, Stat 三种抑制化合物
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关于此项目
经验公式（希尔记法）:
C8H5NO4S
化学文摘社编号:
分子量:
211.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Stattic, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >20 mg/mL
SMILES string
[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI key
ZRRGOUHITGRLBA-UHFFFAOYSA-N
Application
Stattic 用于抑制信号转导子和转录激活因子3（STAT3）的活性，适用各种细胞系和培养物中。
Stattic 用于研究人肺癌细胞中 Stat3 介导的细胞信号传导。5
Biochem/physiol Actions
Stattic 是一种不可逆的 STAT3 活化抑制剂。
Stattic（Stat3 三抑制化合物）改变 Stat3 的 SH2 结构域，间接抑制与磷肽结合。与其他磷酸肽类相比，它易于跨膜转运。2 Stattic 诱导 ROS 形成增加，对心肌细胞线粒体功能产生负面影响， 3 并使鼻咽癌细胞对放化疗敏感。4
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Matthew A Bill et al.
Molecular cancer, 9, 165-165 (2010-06-26)
We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. FLLL32
null
Kerstin Boengler et al.
Current pharmaceutical design, 19(39), 6890-6895 (2013-04-18)
The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S7947-25MG | 04061833221433 |