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S8251

氯化琥珀胆碱二水合物 二水合物

98.0-102.0%, Cholinergic antagonist, solid

别名:

琥珀酰氯化胆碱

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关于此项目

线性分子式:
[(CH3)3NCH2CH2OCOCH2]2Cl2 · 2H2O
化学文摘社编号:
6101-15-1
分子量:
397.34
NACRES:
NA.77
PubChem Substance ID:
24277873
UNSPSC Code:
41116107
EC Number:
200-747-4
MDL number:
MFCD00150564
Beilstein/REAXYS Number:
3922827
Assay:
98.0-102.0%
Form:
solid
Quality level:
100
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产品名称

氯化琥珀胆碱二水合物 二水合物, 98.0-102.0%, solid

Quality Level

100

assay

98.0-102.0%

form

solid

color

white

solubility

H2O: complete 100 mg/ml, clear to slightly hazy, colorless, H2O: soluble (unstable at pH > 9.)

originator

Novartis

SMILES string

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

InChI key

FFSBEIRFVXGRPR-UHFFFAOYSA-L

Application

氯化琥珀胆碱用于研究非洲爪蟾 半胱氨酸环受体的门控机制。4,5

Biochem/physiol Actions

琥珀胆碱是胆碱能拮抗剂和神经肌肉阻断剂。它诱导肌肉膜上乙酰胆碱受体的去极化和肌肉中钾的流出，导致乙酰胆碱受体表达上调的个体发生低钾血症。3
胆碱能拮抗剂，可诱导乙酰胆碱神经元膜的长期去极化；神经肌肉阻断剂。

Features and Benefits

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

Preparation Note

溶液可以在 4℃ 下储存数天。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

危险化学品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCP8101
MKCH8005
MKCC3936
MKBZ5191V
MKBW5278V

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J A Jeevendra Martyn et al.
Anesthesiology, 104(1), 158-169 (2006-01-06)
Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain
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货号GTIN
S8251-25G04061836960612