S8307
SB 203580
≥98% (HPLC), solid, p38 MAPK inhibitor
别名:
4-（4-氟苯基）-2-（4-甲基亚磺酰苯基）-5-（4-吡啶基）-1H-咪唑
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关于此项目
经验公式（希尔记法）:
C21H16FN3OS
化学文摘社编号:
分子量:
377.43
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SB 203580, solid, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
−20°C
SMILES string
CS(=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChI key
CDMGBJANTYXAIV-UHFFFAOYSA-N
Gene Information
Application
使用SB 203580处理MDCK细胞以研究MAPK信号转导在诱导细胞膜的高渗性和钾耗竭中的作用。16 它被用于抑制小鼠皮层神经元17和人肝细胞癌细胞系中的MAPK信号转导。18
Biochem/physiol Actions
SB 203580是一种吡啶基咪唑，可抑制MAPKAP激酶-2的活化，以及在体内抑制热休克蛋白（HSP）27对IL-1、细胞应激和细菌内毒素的反应磷酸化。它不可抑制JNK或p42 MAP激酶，因此可用于研究p38 MAPK和MAPKAP激酶-2的生理作用和靶点。已有研究显示它可诱导丝氨酸/苏氨酸激酶Raf-1的活化，并且据报道其可抑制细胞因子的产生。
Features and Benefits
该化合物是激酶磷酸酶生物学研究的推荐产品。点击此处，了解更多精选激酶磷酸酶生物学产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
S Hashimoto et al.
Biochemical and biophysical research communications, 258(2), 443-447 (1999-05-18)
We examined the regulatory role of a reduction/oxidation (redox) control protein, thioredoxin (TRX), in tumor necrosis factor-alpha (TNF-alpha)-induced p38 MAP kinase activation and p38 MAP kinase-mediated cytokine expression utilizing TRX-transfected murine L929 cells (TRX14). The results showed that TNF-alpha-induced p38
C A Hall-Jackson et al.
Oncogene, 18(12), 2047-2054 (1999-05-13)
The inhibition of SAPK2a/p38 (a mitogen activated protein (MAP) kinase family member) by SB 203580 depends on the presence of threonine at residue 106. Nearly all other protein kinases are insensitive to this drug because a more bulky residue occupies
Harini Lakshminarasimhan et al.
Scientific reports, 7(1), 4533-4533 (2017-07-05)
Doxorubicin (DOX), a common chemotherapeutic agent, impairs synaptic plasticity. DOX also causes a persistent increase in basal neuronal excitability, which occludes serotonin-induced enhanced excitability. Therefore, we sought to characterize and reverse DOX-induced physiological changes and modulation of molecules implicated in
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S8307-1MG | 04061836960735 |