S8751
磺胺胍
别名:
4-氨基-N-(氨基亚氨基甲基)苯磺酰胺, 4-氨基-N-胍基苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C7H10N4O2S
化学文摘社编号:
分子量:
214.24
UNSPSC Code:
51283914
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-345-9
Beilstein/REAXYS Number:
2695326
MDL number:
biological source
synthetic (Organic)
Quality Level
form
powder
color
white to off-white
solubility
1 M HCl: soluble 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
NC(=N)NS(=O)(=O)c1ccc(N)cc1
InChI
1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
InChI key
BRBKOPJOKNSWSG-UHFFFAOYSA-N
Gene Information
human ... F2(2147), PRSS1(5644)
General description
化学结构：磺胺
Application
磺胺胍被用来阻止叶酸的合成。可用于研究其对微孢子生长和宿主细胞活力的影响。
Biochem/physiol Actions
磺胺胍是一种磺胺类抗生素。磺酰胺可通过抑制二氢蝶呤合酶来阻止二氢叶酸的合成。磺胺类药物是细菌对氨基苯甲酸（PABA；细菌中叶酸合成所必需）的竞争性抑制剂。磺胺胍是一种二氢叶酸还原酶（DHFR）的抑制剂。磺胺类药物对革兰氏阳性细菌和革兰氏阴性细菌具有活性。抗性模式是通过二氢蝶呤合酶的改变或叶酸合成的替代途径。
Other Notes
将容器密闭保存在干燥和通风良好的地方。在干燥处保存。储存类别 (TRGS 510)：非易燃固体
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
R F Cross et al.
Journal of chromatography. A, 929(1-2), 113-121 (2001-10-12)
Two electrically neutral analytes previously observed to be separated from the neutral marker in capillary zone electrophoresis (CZE) experiments [sulphanilamide (SAA) and sulphaguanidine (SGW)] have been examined to determine the basis for separation. The degree of separation increases markedly with
L S Wan et al.
Journal of microencapsulation, 12(4), 417-423 (1995-07-01)
Microspheres were formed when a solution of cellulose phthalate was extruded into 30% glacial acetic acid solution. Sulphonamides entrapped in such microspheres leached into the hardening solution because they dissolved freely in the acetic acid solution. This resulted in poor
T W Wong et al.
Journal of microencapsulation, 19(4), 511-522 (2002-10-25)
The potential application of pectin as a matrix polymer for making microspheres by an emulsification technique was explored, and the drug release property of these pectinate microspheres containing drug cores of varying aqueous solubilities: sulphanilamide, sulphaguanidine and sulphathiazole, was investigated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S8751-100G | 04061833613566 |
| S8751-25G | 04061833512937 |
| S8751-500G | 04061833624555 |