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Merck
CN

S8809

Pan单克隆抗 钠通道 小鼠抗

~1 mg/mL, clone K58/35, purified immunoglobulin

别名:

钠通道抗体

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
K58/35, monoclonal
Application:
IF, IHC (f), WB
Citations:
79
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K58/35, monoclonal

species reactivity

mammals

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons, western blot: 1 μg/mL using crude brain membrane prep (rat)

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

General description

电压门控钠通道/VGSCs(Nav)是由膜的去极化启动的跨膜蛋白。它们是具有大的成孔 α-亚基和小的 β-亚基的异质多聚体。

Immunogen

来自细胞内 III-IV Na + 通道环的合成肽 CTEEQKKYYNAMKKLGSKK

Application

小鼠单克隆抗钠通道泛抗体可用于:
  • 免疫组化(1:50)
  • 免疫染色(1:200)
  • 免疫荧光
  • 免疫细胞化学(1:100)

Biochem/physiol Actions

电压门控钠通道/VGSCs(Nav)参与伤害性传导。它们在调节胞外和胞内空间之间的交换方面发挥着关键作用。VGSC 对于动作电位的启动和激发至关重要。它们参与神经元的兴奋性。因此,VGSC 基因的突变会导致几种癫痫疾病。
该克隆识别的序列在所有已知脊椎动物的 Na + 通道中是相同的。在培养的海马神经元中,该抗体可特异性染色轴突起始段。在坐骨神经和视神经中,它可染色郎飞结。

Physical form

溶液含 10 mM Tris (pH 7.5)、 0.1 mNaCl、30% 甘油和 15 mM 叠氮化钠。

Legal Information

由SUNY Stony Brook 独家授权销售。

Disclaimer

除非我们的产品目录或产品随附的其他公司文件中另有说明,否则我们的产品仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。


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分析证书(COA)

Lot/Batch Number

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The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(25), 5988-5997 (2005-06-25)
Disruption of oligodendrocyte lineage progression is implicated in the white-matter injury that occurs in cerebral palsy. We have previously published a model in rabbits consistent with cerebral palsy. Little is known of normal white-matter development in perinatal rabbits. Using a
J-C Platel et al.
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Marie K Bosch et al.
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全球贸易项目编号

货号GTIN
S8809-.1MG04061836961084