S8939
SGK1 (δ1-60, S422D), active human
recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution
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关于此项目
Recombinant:
expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
recombinant
expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
Quality Level
form
buffered aqueous solution
mol wt
~48 kDa by SDS-PAGE
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SGK1(6446)
General description
The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.
Biochem/physiol Actions
The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.
Kinase assays.
Physical form
Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.
Other Notes
One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.
Legal Information
Brij is a registered trademark of Croda International PLC
存储类别
10 - Combustible liquids
法规信息
新产品
此项目有
SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition.
Talarico C
Cellular Physiology and Biochemistry (2016)
mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
Feng Hong
Molecular Cell, 30(6) (2011)
Serum glucocorticoid inducible kinase (SGK)-1 protects endothelial cells against oxidative stress and apoptosis induced by hyperglycaemia.
Ferrelli F
Acta Diabetologica (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S8939-2UG | 04061838073723 |