产品名称
抗-SOX2 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Quality Level
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 34-37 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500, immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
General description
转录因子SOX-2（SOX-2）是SRY相关HMG-box（SOX）转录因子家族的成员，参与调节胚胎发育和确定细胞命运。该基因的突变与双侧失语症有关，双侧失语症是结构性眼畸形的一种严重形式。当SOX-2在自我更新的祖细胞中表达时，它起到抑制神经元分化的作用。相反，SOX-2的主动抑制诱导神经分化。
Immunogen
对应于人SOX2残基32-47的合成肽。
Application
兔多克隆抗Sox2抗体用于标记溶质性别决定区Y-box 2转录因子，以通过免疫细胞化学和免疫组织化学（IHC）技术（例如免疫印迹（~37 kDa）和流式细胞术）进行检测和定量。 它被用作探针来确定性别决定区Y-box 2转录因子在祖细胞自我更新和分化中的存在和作用。
Biochem/physiol Actions
兔多克隆抗SOX2抗体可识别人，小鼠，大鼠性别决定区Y-box 2转录因子。
Physical form
溶于含有 0.02％ 叠氮化钠的磷酸盐缓冲液中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Dasa Dolezalova et al.
Stem cells (Dayton, Ohio), 30(7), 1362-1372 (2012-04-19)
Studies of human embryonic stem cells (hESCs) commonly describe the nonfunctional p53-p21 axis of the G1/S checkpoint pathway with subsequent relevance for cell cycle regulation and the DNA damage response (DDR). Importantly, p21 mRNA is clearly present and upregulated after
Elisa Latorre et al.
Molecular pharmacology, 89(2), 243-252 (2015-12-18)
Since 2005, sex determining region y-box 2 (SOX2) has drawn the attention of the scientific community for being one of the key transcription factors responsible for pluripotency induction in somatic stem cells. Our research investigated the turnover regulation of SOX2
Bartolo Bono et al.
Scientific reports, 8(1), 13838-13838 (2018-09-16)
Cancer stem cells (CSCs) have been involved in the maintenance, progression and relapse of several tumors, but their origin is still elusive. Here, in vitro transformed human fibroblasts (cen3tel cells) and the tumorsphere assay were used to search for and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S9072-100UG | 04061837795244 |