S9576
SR8278
≥98% (HPLC)
别名:
1,2,3,4-四氢-2-[[[5-（甲硫基-2--2-噻吩基]羰基] -3-异喹啉羧酸乙酯
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C18H19NO3S2
化学文摘社编号:
分子量:
361.48
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
lyophilized powder
color
white
solubility
DMSO: ≥30 mg/mL
storage temp.
2-8°C
SMILES string
CCOC(=O)C1Cc2ccccc2CN1C(=O)c3ccc(SC)s3
InChI
1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3
InChI key
UIEBLUZPSFAFOC-UHFFFAOYSA-N
Application
SR8278已被用作核受体亚家族1D组成员1（NR1D1）拮抗剂，以研究其对饥饿诱导的巨噬细胞的作用。
SR8278可用作rev-erbα拮抗剂，研究胰高血糖素分泌对小鼠胰岛α细胞和β细胞的调节作用。
Biochem/physiol Actions
SR8278是核血红素受体REV-ERB拮抗剂。
SR8278是核血红素受体REV-ERB拮抗剂。REV-ERBα通过抑制靶基因活性在调节昼夜节律中起关键作用。另外，研究表明，REV-ERBα可调节脂质和葡萄糖代谢等代谢过程。 SR8278可阻断合成激动剂GSK4112增强REV-ERBα依赖性抑制的能力、刺激参与糖异生的REV-ERBα靶基因的表达。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Dapeng Yu et al.
International immunopharmacology, 73, 312-320 (2019-05-28)
Progressive lung injury and pulmonary inflammation can be induced by an intraperitoneal injection of lipopolysaccharide (LPS). Interleukin-1β (IL-1β) is a key pro-inflammatory cytokine that can further exaggerate inflammation, which is cleaved and activated by the NALP3 inflammasome. Although the nuclear
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy
Chandra V, et al.
Autophagy, 11(11), 1987-1997 (2015)
Elaine Vieira et al.
Endocrinology, 153(2), 592-601 (2011-12-15)
Disturbances of circadian rhythms have been associated with obesity and type 2 diabetes. The nuclear receptor Rev-erbα was suggested to link circadian rhythms and metabolism in peripheral tissues. The aim of the present study was to dissect the role of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S9576-25MG | 04061832824383 |
| S9576-5MG | 04061832824390 |