SAB1302822
抗LGR5（N末端） 兔抗
IgG fraction of antiserum, buffered aqueous solution
别名:
GPR49, GPR67, G蛋白偶联受体49, G蛋白偶联受体67, LGR5, 孤儿G蛋白偶联受体HG38, 富含亮氨酸重复序列的G蛋白偶联受体5 [前体]
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
3
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
99998 Da
species reactivity
hamster
species reactivity (predicted by homology)
mouse
technique(s)
immunohistochemistry: 1:500-1:1000, western blot: 1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... LGR5(8549)
General description
R-spondin受体增强经典Wnt信号通路，并可作为肠上皮和毛囊的干细胞标志物。结合R-spondin（RSPO1、RSPO2、RSPO3或RSPO4）后，它与磷酸化LRP6和卷曲受体（frizzled ）结合，卷曲受体由胞外Wnt受体激活，从而引发经典Wnt信号通路以增加靶基因的表达。与经典G 蛋白偶联受体相比，它不会激活杂三聚体G蛋白以转导信号。参与胚后发育过程中成年肠肝细胞的发育和/或维护。在骨骼肌、胎盘、脊髓和大脑各区域中表达。在结肠和小粘膜干细胞的隐窝基底（base of crypt）中表达。癌前表达不限于隐窝基底。在卵巢、结肠和肝癌中过度表达。
Physical form
纯化的单克隆抗体是含有0.09％（W/V）叠氮化钠的PBS溶液该抗体通过蛋白A柱以及随后的肽亲和纯化进行纯化。
Disclaimer
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Shailender S Kanwar et al.
Molecular cancer, 9, 212-212 (2010-08-10)
Recent evidence suggests that epithelial cancers, including colorectal cancer are driven by a small sub-population of self-renewing, multi-potent cells termed cancer stem cells (CSCs) which are thought to be responsible for recurrence of cancer. One of the characteristics of CSCs
Jun-ichi Satoh et al.
Cellular and molecular neurobiology, 30(3), 415-426 (2009-10-09)
Neural stem cells (NSC) with self-renewal and multipotent properties serve as an ideal cell source for transplantation to treat spinal cord injury, stroke, and neurodegenerative diseases. To efficiently induce neuronal lineage cells from NSC for neuron replacement therapy, we should
Jessica Maddox et al.
PLoS genetics, 8(11), e1003048-e1003048 (2012-11-13)
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription states, regulates normal and pathologic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB1302822-400UL | 04061835592845 |