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SAB1404503

Monoclonal Anti-TYMS antibody produced in mouse

Name: Monoclonal Anti-TYMS antibody produced in mouse
Brand: SIGMA

clone 2B2, purified immunoglobulin, buffered aqueous solution

别名:

MGC88736, HsT422, TMS, TS, TSase

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

2B2, monoclonal

Application:

ELISA (i), IHC (p), IP, WB

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2B2, monoclonal

form

buffered aqueous solution

mol wt

antigen ~37.11 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

NCBI accession no.

BC013919

UniProt accession no.

P04818

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TYMS(7298)

说明

General description

The gene encoding thymidylate synthetase (TYMS) is localized on human chromosome 18p11.32.

Immunogen

TYMS (AAH13919, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
ANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSC

Biochem/physiol Actions

Thymidylate synthetase (TYMS) has a role in DNA replication and thymidylate biosynthesis. It is also involved in cell survival and proliferation. TYMS takes part in folate metabolism. The protein methylates deoxyuridylate to deoxythymidylate.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

09335-2B2

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Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.

Wang T, et al

Proceedings of the National Academy of Sciences of the USA, 101(9), 3089-3094 (2004)

Higher Tissue Levels of Thymidylate Synthase Determined by ELISA Are Associated with Poor Prognosis of Patients with Lung Cancer.

Shiina T, et al.

The Tohoku Journal of Experimental Medicine, 242(4), 303-316 (2017)

Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis.

Wang X, et al.

Clinics and Research in Hepatology and Gastroenterology, 4193), 319-326 (2017)

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全球贸易项目编号

货号	GTIN
SAB1404503-100UG	04061831658132